Ranchi: Scientists have identified promising anti-cancer properties in a traditional five-plant herbal formulation used by the Konyak tribe of Nagaland, marking a significant step in bridging indigenous knowledge and modern medical science.
The preliminary study, conducted by researchers from Nagaland University, Berhampur University, and Saveetha Medical College, found that natural compounds present in the formulation may inhibit tumor growth by blocking angiogenesis—the formation of new blood vessels that fuel cancer development.
According to an official release, the research aims to scientifically validate traditional healing practices while opening new pathways for drug discovery in contemporary medicine.
For generations, indigenous communities worldwide have relied on herbal remedies to treat a wide range of ailments. However, scientific understanding of their efficacy and mechanisms has remained limited. This study addresses that gap by combining traditional knowledge with advanced analytical techniques.
Researchers analyzed the polyherbal formulation using Gas Chromatography–Mass Spectrometry (GC-MS) and computer-based molecular simulations. The findings revealed that the bioactive compounds in the mixture effectively target VEGFR2, a protein that plays a key role in tumor angiogenesis and cancer progression.
The study further indicates that these compounds exhibit strong and stable binding with VEGFR2, suggesting potential for development into anti-cancer drugs. Notably, the compounds demonstrated greater specificity toward VEGFR2 compared to similar proteins, raising the possibility of reduced side effects.
In addition, the compounds showed low toxicity and favorable pharmacokinetic properties, including absorption and distribution, making them promising candidates for future therapeutic use.
The research has been published in the peer-reviewed journal Microchemical Journal.
Nagaland University Vice-Chancellor Prof. Jagdish K. Patnaik said the study exemplifies a meaningful convergence of traditional wisdom and modern science. He noted that such efforts not only recognize indigenous knowledge systems but also contribute to the development of cost-effective and safer medical treatments.
Lead researcher Dr. G. Bupesh highlighted that this is the first comprehensive scientific analysis of the specific five-plant formulation used by the Konyak tribe. He added that several potent bioactive compounds have been identified through advanced methodologies.
Researchers, however, cautioned that the findings are based on preliminary and computational analysis. Further validation through laboratory (in vitro) and clinical (in vivo) studies will be essential, particularly in relation to colon cancer treatment.
The study underscores the broader significance of traditional knowledge as a valuable resource for modern medicine, with the potential to drive innovation in affordable and nature-based healthcare solutions.
(Source: Down To Earth)
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